Preoperative alpha-fetoprotein (AFP) in hepatocellular carcinoma (HCC): is this 50-year biomarker still up-to-date?
نویسندگان
چکیده
منابع مشابه
Hepatocellular carcinoma (HCC) and diagnostic significance of A-fetoprotein (AFP).
BACKGROUND Alpha-fetoprotein (alpha-fetoprotein, AFP) is a Glycoprotein, belonging to the intriguing class of onco-development protein. Generally designated as tumour marker, AFP is recognized as an important blood component, having specific diagnostic utilities Elevation of its level up to pathological range in adults correlate with the appearance of several malignant and chronic conditions, s...
متن کاملCorrelation analysis of preoperative serum alpha-fetoprotein (AFP) level and prognosis of hepatocellular carcinoma (HCC) after hepatectomy
BACKGROUND To investigate the prediction value of preoperative serum alpha-fetoprotein (AFP) level for the prognosis of hepatocellular carcinoma (HCC), by comparing pathological characteristics, recurrence rate and survival rate after hepatectomy. METHODS 108 cases of HCC patients who received liver resection in our hospital from 2005 to 2011 were enrolled in this study. According to preopera...
متن کاملEvaluation of serum AFP (α-fetoprotein) level in HBsAg carrier patients for diagnosis of hepatocellular carcinoma
Background: Hepatocellular carcinoma (HCC) is common all over the world as well as Iran. The incidence of HCC is higher in hepatitis B carriers and it is highly recommended to periodically screen these patients by serum alpha-fetoprotein (AFP) and liver ultrasound (US) every 6 months. We explore the diagnostic accuracy and the performance of (AFP) in cases of hepatitis B carriers as a scree...
متن کاملAlpha-fetoprotein still is a valuable diagnostic and prognosis predicting biomarker in hepatitis B virus infection-related hepatocellular carcinoma
Use of serum alpha-fetoprotein (AFP) in clinical practices has been challenged in recent years, due to the lack of specificity and sensitivity. Here we conducted a retrospective study to evaluate the diagnostic and prognostic value of serum AFP among hepatocellular carcinoma (HCC) patients with their pathogenic features taken into consideration. The cohort for this study comprised 318 cases of ...
متن کاملExcessive alpha-fetoprotein concentrations in hepatocellular carcinoma.
Excessive alpha-fetoprotein concentrations in hepatocellular carcinoma We describe a patient with hepatocellular carcinoma, whose serum concentration of ac-fetoprotein exceeded 4 800 000 ,ug/l and produced an extra band on protein electrophoresis. complaining of severe right shoulder pain and abdominal distension of about two weeks' duration. He had a massively enlarged liver with considerable ...
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ژورنال
عنوان ژورنال: Translational Gastroenterology and Hepatology
سال: 2020
ISSN: 2415-1289
DOI: 10.21037/tgh.2019.12.09